重组小鼠VCAM1(CD106)蛋白（His标记）
货号：106488 编号：XFBM475
CAS号： 规格：VCAM1, CD106, INCAM-100, V-CAM 1, VCAM-1
包装：10 μg 保质期：365天
保存条件：-20℃保存
DESCRIPTION | ||
Gene Name Synonym | VCAM1, CD106, INCAM-100, V-CAM 1, VCAM-1 | |
Species | Mouse | |
Accession | P29533 | |
Source | HEK293 cells | |
SPECIFICATIONS | ||
Amino acid sequence | Phe25-Glu698 is expressed with a 10×His tag at the N terminus | |
Molecular Weight | 78 kDa | |
Purity | >95.0% as determined by SDS-PAGE | |
Endotoxin | <5 EU·mg-1 | |
Formulation | Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. | |
Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. | |
STORAGE | ||
Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. | |
BACKGROUND | ||
Vascular cell adhesion protein 1 (VCAM1) is also known as CD106, INCAM-100 and L1CAM, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes. | ||
Data | ||
SDS-PAGE | Bioactivity | |
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Recombinant Mouse VCAM1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 65-110 kDa. | Immobilized Mouse VCAM1, His Tag at 5 μg/mL (100 μL/well) can bind Anti-VCAM1 with a linear range of 0.004-0.039 ng/mL. | |
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