重组小鼠TIM-3(CD366) 蛋白（His标记）
货号：106472 编号：XFBM471
CAS号： 规格：HAVCR2, TIM3, TIMD3, FLJ14428, KIM3, T-cell immunoglobulin mucin family member 3, TIM-3, CD366
包装：10 μg 保质期：365天
保存条件：-20℃保存
DESCRIPTION | |
Gene Name Synonym | HAVCR2, TIM3, TIMD3, FLJ14428, KIM3, T-cell immunoglobulin mucin family member 3, TIM-3, CD366 |
Species | Mouse |
Accession | Q8VIM0 |
Source | HEK293 cells |
SPECIFICATIONS | |
Amino acid sequence | Arg20-Ala193 is expressed with a 10×His tag at the C terminus |
Molecular Weight | 19.3 kDa（The protein migrates as 20-40 kDa under reducing condition (SDS-PAGE) due to glycosylation） |
Purity | >95.0% as determined by SDS-PAGE |
Endotoxin | <5 EU mg-1 |
Formulation | Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. |
Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. |
STORAGE | |
Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. |
BACKGROUND | |
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis. | |
Data | |
SDS-PAGE | Bioactivity |
| Testing in progress |
Recombinant Mouse TIM3 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 30-50 kDa. | |
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