重组人CD354 蛋白（His标记）
货号：106428 编号：XFBM464
CAS号： 规格：TREM1, CD354, TREM-1
包装：10 μg 保质期：365天
保存条件：-20℃保存
DESCRIPTION | |
Gene Name Synonym | TREM1, CD354, TREM-1 |
Species | Human |
Accession | Q9NP99 |
Source | HEK293 cells |
SPECIFICATIONS | |
Amino acid sequence | Ala21-Asn205 is expressed with a 10×His tag at the C terminus |
Molecular Weight | 20.2 kDa |
Purity | >95.0% as determined by SDS-PAGE |
Endotoxin | <5 EU mg-1 |
Formulation | Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. |
Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. |
STORAGE | |
Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. |
BACKGROUND | |
CD354, Triggering Receptor of Myeloid Cells-1(TREM-1), is a potent amplifier of myeloid immune responses. CD354 is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes.TREM-1 potently amplified the function of TLR and Nod-like receptors (NLR) which resulted in enhanced cytokine production. TREM-1 was first described as a costimulatory receptor on myeloid cells. Antagonizing TREM-1 with antibodies, fusion proteins, or inhibitory peptides reduces inflammation in experimental arthritis and colitis models.TREM-1 mRNA and protein were elevated in inflammatory bowel disease, experimental colitis, inflammatory arthritis, and other noninfectious inflammatory diseases.TREM1 performs a critical function in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock. | |
Data | |
SDS-PAGE | Bioactivity |
| Testing in progress |
Recombinant Human CD354 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 35-60 kDa. | |
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