重组人CD333蛋白（His标记）
货号：106418 编号：XFBM463
CAS号： 规格：FGF R3 (IIIc), FGF R3C, CD333
包装：10 μg 保质期：365天
保存条件：-20℃保存
DESCRIPTION | |
Gene Name Synonym | FGF R3 (IIIc), FGF R3C, CD333 |
Species | Human |
Accession | P22607 |
Source | HEK293 cells |
SPECIFICATIONS | |
Amino acid sequence | Glu23-Gly375 is expressed with a 8×His tag at the C terminus |
Molecular Weight | 42.1 kDa |
Purity | >95.0% as determined by SDS-PAGE |
Endotoxin | <5 EU mg-1 |
Formulation | Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. |
Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. |
STORAGE | |
Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. |
BACKGROUND | |
Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways. The FGFR3 gene is at the human chromosomal locus 4p16.3 also encodes two isoforms: FGF R3 (IIIb) FGF R3 (IIIc). Upregulated expression of FGFR3 protein is also found in a significant number of tumors. Additionally, FGFR3 has been found to trigger resistance to tamoxifen via the activation of the PLCγ signaling cascade. | |
Data | |
SDS-PAGE | Bioactivity |
| Testing in progress. |
Recombinant Human CD333 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 60-100 kDa. | |
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